47 XXY

Incidence

 * 1/1,000 males

Molecular Etiology

 * 80% XXY
 * Maternal Meiotic Error: 50%
 * Paternal Meiotic Error: 50%


 * 10% Mosaic
 * 10% Variants
 * XXXY, XXXXY

Endocrine/Growth

 * Gynecomastia
 * Female Body Habitus
 * Small Testes
 * Infertility
 * Tall Stature

Neurological

 * Learning Disabilities
 * Developmental Delay
 * Fine/Gross Motor

Malignancies

 * Male Breast Cancer = risk increased

Prognosis

 * Life Expectancy = Normal
 * Phenotype Severity Correlates to Number of Xs

Recurrence Risk

 * General Population Risk